After months of contentious battles on Capitol Hill, which included numerous last-minute and unsubstantiated allegations of sexual misconduct, the US senate approved Kavnauagh's nomination in a narrow vote Saturday that fell down party lines.
Protesters in the Senate Gallery interrupted the vote by yelling and were escorted out of the building by security.
Manchin (D-W.V.) was seen as one of the possible swing votes on Kavanaugh, but on Friday he came out as the lone Democrat to support President Trump's pick for the high court.
The path to Kavanaugh's confirmation cleared on Friday when two wavering Republicans, Susan Collins of ME and Jeff Flake of Arizona, said they would vote for Kavanaugh after concluding that Ford's allegations, voiced by her in an emotional hearing last week, could not be corroborated.
The prolonged nomination battle has roiled American politics and passions - the vote was disrupted on several occasions by angry protests from the gallery - but handed Trump one of the biggest victories of his presidency.
Kavanaugh was accused in September of committing sexual and physical assault more than 30 years ago, and he testified about the alleged incident at a hearing with the Senate Judiciary Committee last week.
Sen. Susan Collins said Saturday that while she believes that Dr. Christine Blasey Ford was sexually assaulted, she does not believe that now-confirmed Supreme Court Justice Brett Kavanaugh did it.
Collins told Bash that while she found Ford's testimony "heart-wrenching", the fact that both Ford and Kavanaugh said they were "100 percent certain" of their statements meant that she had to look to the Federal Bureau of Investigation for additional corroborating evidence. Afterward, Republicans declared that the FBI had not found any corroborating witnesses, while Democrats blasted the limited scope of the investigation, which they said ignored dozens of witnesses willing to corroborate allegations of sexual misconduct and lying under oath.
Manchin was the only Democrat to vote for Kavanaugh's confirmation.
In Washington, President Donald Trump said Saturday that he thought Collins was "incredible" and that she "gave an impassioned, handsome speech".
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Kavanaugh has denied the allegation . "You, sir, under historic scrutiny, were proven innocent", Trump said to Kavanaugh. Ford a liar, they all agreed to say she was a victim, but too dumb or hysterical to know who her perpetrator was.
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The final tally, 50-48-1, was every bit as razor-thin as the national fault-line that rumbled under weeks of hearings for the man Trump nominated to replace retired Justice Anthony Stevens.
"Senators claiming to want a dignified debate should not repeat lies constructed by the Judiciary Committee that were cynically created to win support for Judge Kavanaugh".
Ford's allegations disrupted what had appeared to be a relatively smooth confirmation process for Kavanaugh.
"I never considered asking him or asking the president to withdraw the nomination".
Mira Sorvino, one of the actresses to accuse disgraced producer Harvey Weinstein of sexual harassment - which he denies, expressed her fears Mr Kavanaugh will help protect the president from any potential legal action.
The judge, who is a darling of the Republican and libertarian organisation the Federalist Society, has been the subject of a host of sexual assault allegations since being nominated by U.S. president Donald Trump.
"Hey Hey, Ho, Ho, Kavanaugh has got to go", they shouted. Daines was willing to take a private jet immediately back to Washington if necessary to cast the deciding vote, but Murkowski - the only Republican to oppose Kavanaugh - agreed to vote "Present" instead of "No" on the final vote, to neutralize the effect of Daines' absence and keep the two-vote margin for Kavanaugh's confirmation.
"Very late in the confirmation process serious allegations were made against Judge Kavanaugh".
Hundreds of people rallied in front of Trump Tower then walked to Times Square to protest Supreme Court nominee Brett Kavanaugh. Trump said he was "100 percent" certain Kavanaugh was innocent.