At the Conservative Party annual conference in Birmingham, she's asked all party members - whichever side of the question they stand on - to pull together.
And after a day in which Boris Johnson stole the show at the conference with his chuck Chequers onslaught, the Prime Minister will attempt to re-assert her authority.
Taking a swipe at Mr Johnson, Mrs May said she was taking decisions on Brexit in the "national interest", pressing her argument that her former foreign secretary's alternative Brexit proposals would tear the United Kingdom apart.
But the European Union is demanding new proposals from Britain before it signs a deal - and many Conservatives are in no mood to compromise.
The pressure she is under from some in the party was underlined less than an hour before she was due to speak when Conservative legislator James Duddridge said he had submitted a letter to the party's so-called 1922 committee, calling on her to resign. We need a strong leader, someone who believes in Brexit and someone to deliver what the electorate voted for.
Looking ahead to the PM's speech, Johnson ally Jacob-Rees Mogg told Sky News: In an ideal world I'd like her to say that she's chucking Chequers and she's going to have a super-Canada deal. British Prime Minister Theresa May on Wednesday ruled out the possibility of a second Brexit referendum, saying the second referendum would be a "politicians' vote". The EU is adamant that you can't have the free movement of goods without accepting EU workers. A party of patriotism but not nationalism.
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Now the purchase of the Russian missile system will "test the resilience of the relationship between the US and India ", said C. Uday Bhaskar, a security expert and director of the Society for Policy Studies in New Delhi .
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Ms Chattoe, who has beat breast cancer twice herself and lost her sister to the disease, saw her mother pass away over the summer. It is a screening, not the more extensive diagnostic examination usually applied to patients with symptoms or at severe risk.
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The transcript issued hours later omitted Vega's word " thinking " and showed Trump saying, 'I know you're not thanking '. ABC's Cecilia Vega and CNN's Kaitlan Collins are two new targets for President Donald Trump . "She's in a state a shock".
Cable said that May said the Conservatives must be a party for the whole country, adding "yet she has overseen widening divisions in our society".
Ian Lavery, chair of the main opposition Labour Party, said: "While the country is crying out for real change, all Theresa May and her party offer are pinched ideas and tinkering around at the edges, relying on petty attacks to cover up their lack of vision". You tell us, essentially, the same story - that the British are proposing unrealistic terms that they can't get.
Any spending increases would not be expected to kick in until next year's spending review in any event; but it will be hard for the chancellor to avoid a shift of tone, after her upbeat rhetoric about voters' sacrifices paying off. Many Conservatives expect her to face a leadership challenge soon after Britain leaves the bloc - or even before. On the domestic front, the British PM set an agenda that moved away from austerity and cuts to public services and announced new borrowing powers for local councils to build more homes. The June 2016 referendum on leaving the European Union exposed deep ideological divisions within the party (and, needless to say, the country as a whole) and May has struggled to unite party members, and her own Cabinet, around her Brexit proposals.
It continued: "By publicly pretending to back Theresa May after verbally chucking her under the bus, he showed himself as a yellow-bellied coward". So, it is no surprise that we have had a range of different views expressed this week.
"Emotional arguments that stress the issue of dignity sound attractive, but they do not facilitate agreement".
"If we get it wrong, if we bottle Brexit now, believe me, the people of this country will find it hard to forgive", he told attendees, adding "If we get it wrong, if we proceed with this undemocratic solution, if we remain half in, half out, we will protract this toxic tedious business that is frankly so offputting to sensible middle-of-the-road people who want us to get on with their priorities".