Criticised for his poor shots-to-goals-conceded ratio at the World Cup, De Gea produced a superb save to deny Rashford's header and preserve Spain's lead in the 35th minute, giving his defence the confidence to shut England out from then.
This was Shaw's first match for England since he was recalled to the national team by England manager, Gareth Southgate.
The Manchester United fullback took to twitter to thank all those who showed support and concern while he was still unconscious, saying, "Thank you for all the love and support".
England were chasing shadows and when Kieran Trippier dived in to foul Marcos Alonso in the 32nd minute, the resulting free kick by Alcantara caught the home defence napping as Rodrigo guided the ball home at the near post.
Luke Shaw, making his first worldwide start in three years, was taken off on a stretcher wearing a neck brace and oxygen mask early in the second half after a clash with Dani Carvajal, and the hosts failed to mount a comeback in his absence.
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News of the letter caught up with Pompeo in New Delhi, where he was traveling with US Defense Secretary Jim Mattis . Trump responded to the op-ed in a previously scheduled White House meeting with sheriffs from across the country.
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Sloane Stephens , of the United States, reaches for a shot from Elise Mertens, of Belgium, during the fourth round of the U.S. But having returned to tennis in 2015, Sevastova has risen steadily through the ranks and is now ranked No 18 in the world .
Danny Rose will take over from Luke Shaw and there might also be starts for Jack Butland, James Tarkowski and Fabien Delph in what will be a calculated gamble on Southgate's part, facing a side that regularly features in the top 10 of Fifa's world rankings.
The Three Lions came close to equalising in injury time after De Dea dropped the ball on Welbeck before the Arsenal forward finished from close range.
In a clip that is doing the rounds, "Lucho" gave the La Roja skipper a special greeting when they linked up for the first time ahead of UEFA Nations League games against England and Croatia.
"We have got 19 matches, it's not very long, but, in my opinion, we have got the best group of players in the country here". He is one of the best goalkeepers in the world and has proven it in the Premier League week in, week out. "I've seen teams fold in similar circumstances".
England reached the semi-finals in Russian Federation, but lost to Croatia and then fell to Belgium in the third-place game.