The Palestinian health ministry says a man was moderately wounded by shrapnel, but didn't say whether he was inside a militant site or nearby.
Children in Gaza, who make up the majority of the population, are still struggling with the trauma of previous rounds of violence and war, terrified of another attack and more death and destruction.
Israeli-Palestinian tensions have been on the rise since December, when US President Donald Trump announced the recognition of Jerusalem as the capital city of Israel, triggering furious protests violently suppressed by the IDF.
"We call for a credible global investigation into the crimes committed by the occupation", Arab League chief Ahmed Abul Gheit said at an extraordinary meeting of Arab foreign ministers in Cairo on Thursday to discuss the violence.
Omar Shakir, the local director for Human Rights Watch, said that if they were unarmed, the identity of the slain protesters and their affiliation to a militant group has little to do with Israel's right under worldwide law to use lethal force at a demonstration.
"Violent clashes erupted Monday between Palestinian protesters and the IDF on the Gaza border on the backdrop of the opening of the new U.S. Embassy in Jerusalem", YNetNews.com explained.
President Reuven Rivlin called for restraint on Thursday in the wake of a fresh row between Israel and Turkey over the killing by Israeli forces of 60 Palestinians earlier this week during protests on the Gaza border.
Prime Minister Narendra Modi had visited Palestine in February.
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But with the images of rifle-toting Israeli snipers facing off against seemingly unarmed protesters beamed around the world, the remarks by Hamas may do little to convince Israel's detractors, including the Palestinians.
At a border protest encampment east of Gaza City, Palestinian factions, including Hamas and Islamic Jihad, urged people to take part in mass rallies on Friday.
The US embassy move has been universally condemned.
Palestinian want Arab East Jerusalem, which was captured in the 1967 Middle East war, as the capital of a future Palestinian state.
Netanyahu said it was fitting, noting that Guatemala also followed the U.S.to be the second country to recognize Israel 70 years ago.
Pushing back against foreign censure of its army's actions, Israel has - with Washington's backing - accused Hamas of using civilians as cover for attacks across the frontier fence and to distract from Gaza's internal problems. "Bullets should be regarded as missiles, and Hamas is responsible for everything that happens in Gaza", said Davidi. Dozens of people were killed and 2,700 were wounded. Israel's military said those comments proved the protests were not peaceful.
Erdogan on Tuesday said "Netanyahu is the PM of an apartheid state".