Former West Ham star Payet told the BBC: "We know how tough it is". It is going to be quite a mission.
Speaking at his pre-match press conference, which was covered by uefa.com, Simeone said: "I wasn't on the sidelines for the Arsenal game and it's the same tomorrow".
Taking over as Atletico manager in December 2011, Simeone has managed 375 games for the club, leading them to five trophies. When you get here, you need to have humility, to work.
They'll face something of a surprise opponent there in Marseille, but don't think the French club will have any sort of home advantage here - there's been no love lost between their fans and those from Lyon in recent years. "In the second half they raised their level and the best team won".
A spot in the 2018-19 Champions League could very well be on the line for Rudi Garcia's squad, as they now trail Lyon by one point with one match remaining for the final UCL qualifying spot in Ligue 1.
Marseille, meanwhile, has never won the Europa League title, now three times finishing as a runner-up, and entered the day hoping to claim its first piece of European silverware since winning the Champions League title back in 1993.
And veteran midfielder Gabi hopes the 27-year-old remains at Atletico beyond this season's Europa League showpiece.
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PREDICTION The first of two upcoming European club finals takes place this evening as Atletico Madrid take on Marseille for the right to be called Europa League winners for 2018.
It is hard to ignore the tactical battle that is likely to unfold, with Marseille's exuberance set to clash with Atletico's rigidness.
Marseille reached the final thanks to an extra time victor from defender Rolando, to squeeze past Red Bull Salzburg, 3-2 on aggregate. I wish it won't be his last final with Atletico.
But before we all go ahead and start saying how Griezmann is hilariously original with doing these celebrations, the first group I remember seeing do this is the UMBC basketball team.
However, should they prevail over Atletico, Marseille can go into next season boasting an astute coach getting the most out of a talented squad, financial backing and a spot in Europe's most prestigious competition. Both teams are very pragmatic and play a similar style.
Atletico Madrid have built a reputation under head coach Diego Simeone of being something of a rebel against the bigger, more established clubs in Spain, but if they want to convince Antoine Griezmann to stay that likely won't be a strong enough argument.