It opens there May 11.
In addition, Avengers: Infinity War exceeded expectations by beating The Fate of the Furious (2017) with $541.9 million for the biggest global opening as well. The previous record of $247.9 million was made by "Star Wars: The Force Awakens" three years ago.
By comparison, the first Avengers film had opened to $207 million in 2012 - a record back then. The studio's last movie, Black Panther, grossed a milestone US$1 billion (NZ$1.41b) in its first 26 days.
The 19th film in the Marvel Cinematic Universe brought Marvel's worldwide tally to $15 billion. Moving up the date put some distance between the picture, another Marvel film called "Deadpool 2" set for 18 May and another "Star Wars" movie due 25 May.
Avengers: Infinity War is in theaters now. IMAX screenings accounted for a record $41 million of the weekend's global ticket sales.
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"This isn't an old franchise that their parents saw when they were 20", Greg Foster, head of entertainment for IMAX, told the Associated Press. The company's summer slate will be key in reviving the North American box office and generating growth for theatre owners after a tough 2017. Outside of the MCU, the Infinity War total ranks fourth all time.
Marvel's latest adventure launched with $250 million from 4,474 locations in North America and $380 million in 52 markets internationally for a grand total of $630 million. The film sees the Avengers fight along with the Guardians of the Galaxy and Doctor Strange (Benedict Cumberbatch) to fight one common enemy - Thanos (voiced by Josh Brolin).
"This brought the world together this weekend", said Dergarabedian.
"We're not going to Hall H this year". Its characters aren't introduced; they just show up, and their behavior is entirely defined by the template set for them in other movies.
Estimated ticket sales for Friday through Sunday at USA and Canadian theaters, according to comScore.
Final numbers are expected Monday.