So it was no surprise when the pair were named amongst the six nominees for PFA Player of the Year.
The Belgium worldwide was the leading contender heading into the second half of the Premier League season but De Bruyne's form has dipped in recent weeks.
The winners will be revealed at the PFA Awards on Sunday, 22nd of April.
De Bruyne has been the catalyst for the Citizens' unrivalled march to the Premier League title and had been the favourite to scoop the award for most of the season although the bookies have recently awarded that title to his main rival.
De Bruyne has been the standout player in the incredible Manchester City side that have stormed the Premier League this season.
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He has scored 39 goals and 11 assists in 44 games in all competitions in his first season at the Anfield.
Kane and Salah had a phenomenal 54 Premier League goals between them heading into the weekend.
Premier League legend Alan Shearer has given his backing to the Liverpool star to take the top prize and believes the Champions League tie between City and the Merseysiders to be the deciding factor.
Sessegnon is the youngest player on the list at 17.
Sané is also up for the PFA Young Player of the Year award, one of three Manchester City players on the shortlist with Raheem Sterling and Ederson, who has enjoyed a fine debut year in England.
Sane, 22, has been nominated in both Player and Young Player of the Year categories as has Kane, a victor in 2015.