Irish media is reporting the fire broke out in a mid-level floor of the 15-storey Metro Hotel in Ballymun, in north Dublin just after 8pm (local time).
The hotel is located near the Dublin airport.
Broadcaster TV3 said firefighters had evacuated "everyone" from the three-star hotel - although it is not clear if there are injuries. The firefighting operation was massive and included 8 fire engines, 60 firefighters, ambulances and paramedics, aerial units and more.
At least five of the top floors appeared to be destroyed in last night's fire.
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Anthony Flynn, CEO of Inner City Housing Homeless, told The Journal that he was in contact with Dublin City Council.
Independent councillor Noeleen Reilly tweeted late yesterday: "Starting to look like fire is now under control from (Dublin Fire Brigade)".
It is understood the building has hotel rooms and private rental apartments.