A collapse of the Iran nuclear deal would be a "great loss", the United Nations atomic watchdog's chief warned U.S. President Donald Trump on Monday, giving a wide-ranging defence of the accord and his agency's work under it.
The Iranian foreign ministry on Sunday dismissed Le Drian's concerns, stressing that Tehran will "continue its defense policies independently".
Iran is not allowed to enrich uranium beyond 3.67 percent fissile purity under the deal, a level that is suitable for fuelling some civilian nuclear power stations and far short of the 80-90 percent that is considered weapons grade.
Washington put pressure on the European signatories of the agreement to impose some clauses against the Iranian missile program that does not fall within the spirit and letter of the nuclear agreement.
Le Drian did not meet with anyone from Iran's Revolutionary Guard, a paramilitary force that answers only to Supreme Leader Ayatollah Ali Khamenei and runs the ballistic missile program.
Hardline Iranian media reacted angrily to Le Drian's visit with headlines like "The Rude Guest" and "Weapons of mass seduction".
Le Drian had been scheduled to visit Tehran earlier but postponed his trip after protests across Iran in late December and early January that saw at least 21 people killed.
"The Iranian authorities told me of their heavy concerns on the humanitarian situation in Syria and their desire to see an end to this catastrophe", Le Drian told reporters.
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President Donald Trump has repeatedly threatened to withdraw the United States from the landmark 2015 agreement, and past year refused to confirm to Congress that it is in America's national security interest.
Iran's missiles can now hit any point in the Middle East, including Israel and U.S. military bases, as well as parts of Europe.
Iran has refused any re-negotiation or additional clauses, arguing that the United States has already failed to keep up its end of the bargain on the existing accord.
The Iranian official called for the acceleration of implementation of the Iranian nuclear deal.
Le Drian arrived in Tehran on Monday for talks with Iranian officials on mutual ties as well as regional and worldwide issues.
Amano said Iran was implementing its commitments under the deal, which also lifted painful economic sanctions against the Islamic Republic.
In his interview, Kamalvandi said that Iran has developed highly advanced centrifuges that are 24 times more powerful than the previous models used.
IAEA director general Yukiya Amano said on Monday that losing the nuclear deal "would be a great loss for nuclear verification and for multilateralism".