The Britain-based Syrian Observatory for Human Rights said Monday's airstrikes and shelling killed around 100 people.
"The recent escalation of violence compounds an already precarious humanitarian situation for the 393,000 residents of East Ghouta, many of them internally displaced, and which account for 94 percent of all Syrians living under besiegement today", Moumtzis said.
Ghouta has not seen a single humanitarian aid convoy for two months.
There was no comment from the Syrian military. The Saqba Hospital, Saqba Maternity Hospital and Al Hayat Hospitals were also attacked and put out of service.
But time appeared to be running out for an agreement Sunday and regime forces, who have been receiving aerial backing from Russian Federation, looked on the brink of starting a major offensive. He said most of the dead were women and children.
Syrian state media did not report attacks on East Ghouta on Monday, though reported "shells fired by armed groups" into government territory injured ten people.
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However, the National Emergency Management Emergency (NEMA) zonal coordinator, Bashir Garza, put the death toll at 17 and 51 injured.
The United Nations said last week that civilians in Syria were suffering through some of the worst fighting of the entire conflict, which is entering its eighth year. "There is nowhere to hide", Omran al-Doumani, a photographer from Eastern Ghouta told Middle East Eye.
Syria has been embroiled in a civil war since 2011.
Attacks in Eastern Ghouta in recent weeks have provoked an global outcry.
If a deal is struck for Eastern Ghouta, jihadists would likely be sent to the northwestern province of Idlib, which nearly completely escapes government control. They said that events in their suburb are playing out similarly to the 2016 offensive in Aleppo, when rebels and ISIS militants were expelled by a government offensive that reduced much of the city to rubble.
Due to soaring food prices, impoverished families have been subsisting on one meal a day since the army tightened its siege last November. The sheer intensity of airstrikes is leveling the city, and killing civilians without any regard or mercy.
The area is made up of 22 communities.