After a short stay in Mexico, Tillerson travels to Argentina, followed by Peru, Colombia and Jamaica.
Mr Tillerson noted that China was now the largest trading partner of Chile, Argentina, Brazil and Peru. That involvement included people in Russian Federation buying 3000 USA political ads and placing 80,000 Facebook posts seen by 126 million Americans over two years, Facebook has said.
Mexico is trying to prove itself a good USA ally in hopes of getting a favorable outcome from renegotiations of the North American Free Trade Agreement with Canada and the United States.
Although he offered few details, Tillerson listed trade deals as a priority, including the ongoing negotiations with Canada and Mexico to "modernize" the North American Free Trade Agreement.
"I'm a Texan, former energy executive, and I'm also a rancher. I understand how important NAFTA is for our economy and that of the continent", Tillerson said.
Tillerson acknowledged the huge role of North American trade in the United States economy.
The four Latin American countries that will visit Tillerson during seven days are those that have a harder position against the Venezuelan government in the region and participate in the Group of Lima focused on restoring Venezuela to democracy.
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Tillerson is also expected to rally the region's governments in pressing democratic reforms in crisis-ridden Venezuela. "There has not been any natural disaster, its citizens suffer because a corrupt regime robs its people". "The great tragedy is that although Venezuela could be one of most prosperous countries in the region, it is one of the poorest in the world".
He had similar words for Cuba, where an upcoming regime change is an "opportunity.to take a new direction".
"Obviously that would be something that we strongly want to avoid", Videgaray said at an event in NY late previous year, reffering to NAFTA collapsing.
"We will continue to press the regime to return to the democratic process", Tillerson said.
Attention also must be paid to security threats in the region, particularly to transnational criminal organizations - cartels involved in drugs, human trafficking and smuggling - that pose "the most immediate threat to our hemisphere", he said. Because the US economy is very intertwined with Latin America, changes in the area can affect the U.S and consumers, according to Will Inboden, a UT professor and the Clement Center for National Security executive director.
On some positions, Trump has softened his rhetoric since his inauguration a year ago, but in this week's State of the Union address he spoke more about cross-border crime and immigration than any other foreign policy topic.