Green Bay started the game by recovering an onside kick, only to turn the ball over on a deflected interception while marching on the opening drive.
The Lions 9-7 record is likely not enough to save coach Jim Caldwell's job.
Minnesota Vikings running back Latavius Murray (25) rushes during the first half of an NFL football game against the Detroit Lions, Thursday, Nov. 23, 2017, in Detroit.
He followed it up with a stellar final game against the Packers, completing 20 of 29 passes for 323 yards and three touchdowns passes.
Quarterback Matthew Stafford then hit rookie Kenny Golladay with a 54-yard scoring strike for a 10-3 Lions lead with 7:27 to go until intermission.
With Roberts out, Hakeem Valles will serve as the Lions No. 3 tight end on Sunday against the Packers.
Biggest pregame story lines heading into Bucs vs. Saints
The Buccaneers (4-11) scored on a pair of 1-yard runs, the first by Peyton Barber and the second by quarterback Jameis Winston . Former LSU linebacker Kwon Alexander nailed him one yard short, though, and the Saints turned the ball over on downs.
George Weah: Atiku, Secondus react to victory
Weah also ran in the country's last two elections, winning the first round of the 2005 vote that eventually went to Sirleaf. Former Vice President Atiku Abubakar has congratulated new president of Liberia George Weah on his victory.
Salvation Army, United Blood Services Need Your Help
United Blood Services strives to keep a five-day supply of every blood type at all times. Book an appointment by downloading the GiveBlood app or visit blood.ca.
Brett Hundley was a disappointing 14-of-24 for 174 yards.
The Vikings (9-2) took a huge step toward winning the NFC North, taking a three-game lead over the second-place Lions. Stafford then connected with Marvin Jones Jr. on a 3-yard TD pass to increase the bulge to 17-3 with 2:20 left until halftime.
McCarthy may make changes on his coaching staff this offseason, but he refused to talk about anything not related to the season-ending loss.
Lions defensive end Ezekiel Ansah, in the last year of his contract, had three sacks for the second straight week to give him 12 this season and 44 in his five-year career.
Lions: RB Theo Riddick (ribs), CB Teez Tabor (shoulder) and S Don Carey (knee) were hurt during the game.